Epithelial Biology and Secretion Role of SHP2 protein tyrosine phosphatase in SERT inhibition by enteropathogenic E. coli (EPEC)
نویسندگان
چکیده
Megha Singhal, Christopher Manzella, Vinay Soni, Waddah A. Alrefai, Seema Saksena, Gail A. Hecht, Pradeep K. Dudeja, and Ravinder K. Gill Division of Gastroenterology and Hepatology, University of Illinois at Chicago, Chicago, Illinois; Jesse Brown Veterans Affairs Medical Center, Chicago, Illinois; Department of Physiology and Biophysics, University of Illinois at Chicago, Chicago, Illinois; and Division of Gastroenterology and Nutrition, Departments of Medicine, Microbiology/Immunology, Loyola University Chicago, Chicago, Illinois
منابع مشابه
Role of SHP2 protein tyrosine phosphatase in SERT inhibition by enteropathogenic E. coli (EPEC).
Enteropathogenic Escherichia coli (EPEC), one of the diarrheagenic E. coli pathotypes, is among the most important food-borne pathogens infecting children worldwide. Inhibition of serotonin transporter (SERT), which regulates extracellular availability of serotonin (5-HT), has been implicated previously in EPEC-associated diarrhea. EPEC was shown to inhibit SERT via activation of protein tyrosi...
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Enteropathogenic E. coli (EPEC) belongs to a group of bacterial pathogens that induce epithelial cell actin rearrangements resulting in pedestal formation beneath adherent bacteria. This requires the secretion of specific virulence proteins needed for signal transduction and intimate adherence. EPEC interaction induces tyrosine phosphorylation of a protein in the host membrane, Hp90, which is t...
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